Asset Details
Do you wish to reserve the book?
Biomarkers of blood–brain barrier and neurovascular unit integrity in human cognitive impairment and dementia
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Biomarkers of blood–brain barrier and neurovascular unit integrity in human cognitive impairment and dementia
Do you wish to request the book?
Biomarkers of blood–brain barrier and neurovascular unit integrity in human cognitive impairment and dementia
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Biomarkers of blood–brain barrier and neurovascular unit integrity in human cognitive impairment and dementia
2025
Overview
Blood–brain barrier (BBB) dysfunction is recognized as an early step in the development of Alzheimer's disease and related dementias (ADRD). Biomarkers are needed to monitor BBB integrity over time, better understand the role of the BBB in neurodegeneration, potentially help define long‐term ADRD risk, and monitor effects of therapeutics. In this review, we discuss the current biomarkers used to detect human BBB dysfunction in the context of cognitive decline and dementia. We also discuss promising candidate fluid biomarkers to detect BBB dysfunction in blood. Highlights BBB permeability occurs during normal aging and is further exacerbated in ADRD. In this review, we discuss in vivo imaging and CSF biomarkers of BBB dysfunction currently used in the setting of aging and ADRD in humans. We also review promising candidate blood‐based biomarkers that may represent BBB dysfunction.
Publisher
John Wiley and Sons Inc
