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RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt-β-Catenin Signaling
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RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt-β-Catenin Signaling
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Journal Article
RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt-β-Catenin Signaling
2013
Overview
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered \"rogue\" kinases, because their enzymatic activity appears unregulated. Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt–β-catenin network, where it acts as a regulatory subunit of CK1ε: In a Wnt-dependent manner, DDX3 binds CK1ε and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled. DDX3 is required for Wnt–β-catenin signaling in mammalian cells and during Xenopus and Caenorhabditis elegans development. The results also suggest that the kinase-stimulatory function extends to other DDX and CK1 members, opening fresh perspectives for one of the longest-studied protein kinase families.
Publisher
American Association for the Advancement of Science
Subject
Adaptor Proteins, Signal Transducing - metabolism
/ Animals
/ Caenorhabditis elegans - genetics
/ Caenorhabditis elegans - growth & development
/ Caenorhabditis elegans - metabolism
/ Caenorhabditis elegans Proteins - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ Casein Kinase Iepsilon - chemistry
/ Casein Kinase Iepsilon - metabolism
/ DEAD-box RNA Helicases - chemistry
/ DEAD-box RNA Helicases - genetics
/ DEAD-box RNA Helicases - metabolism
/ Division
/ Embryos
/ Genes
/ Humans
/ Kinases
/ mice
/ mitosis
/ mutation
/ non-specific serine/threonine protein kinase
/ Pathways
/ Phosphoproteins - metabolism
/ Proteins
/ RNA
/ Xenopus
