Journal Article

Recent successes in heart failure treatment

Lam, Carolyn S. P., Ho, Jennifer E., Myhre, Peder L., Omland, Torbjørn, Docherty, Kieran F., McMurray, John J. V.

2023

Overview

Remarkable recent advances have revolutionized the field of heart failure. Survival has improved among individuals with heart failure and a reduced ejection fraction and for the first time, new therapies have been shown to improve outcomes across the entire ejection fraction spectrum of heart failure. Great strides have been taken in the treatment of specific cardiomyopathies such as cardiac amyloidosis and hypertrophic cardiomyopathy, whereby conditions once considered incurable can now be effectively managed with novel genetic and molecular approaches. Yet there remain substantial residual unmet needs in heart failure. The translation of successful clinical trials to improved patient outcomes is limited by large gaps in implementation of care, widespread lack of disease awareness and poor understanding of the socioeconomic determinants of outcomes and how to address disparities. Ongoing clinical trials, advances in phenotype segmentation for precision medicine and the rise in technology solutions all offer hope for the future. Recent years have seen major advances in heart failure treatment, but gaps in implementation and disparities in care remain; this Review outlines the current state of the field.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/154/436/108 / 692/699/75/230 / Amyloidosis / Amyloidosis - therapy / Biomedical and Life Sciences / Biomedicine / Cancer Research / Cardiomyopathies / Cardiomyopathy / Cardiomyopathy, Hypertrophic - genetics / Cardiomyopathy, Hypertrophic - therapy / Clinical trials / Congestive heart failure / Ejection fraction / Health services / Heart failure / Heart Failure - therapy / Humans / Infectious Diseases / Metabolic Diseases / Molecular Medicine / Neurosciences / Phenotypes / Precision medicine / Review Article