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Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella
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Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella
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Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella
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Journal Article
Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella
2023
Overview
Kinesin-1, also known as conventional kinesin, is widely used for microtubule plus-end-directed (anterograde) transport of various cargos in animal cells. However, a motor functionally equivalent to the conventional kinesin has not been identified in plants, which lack the kinesin-1 genes. Here we show that plant-specific armadillo repeat-containing kinesin (ARK) is the long sought-after versatile anterograde transporter in plants. In ARK mutants of the moss Physcomitrium patens, the anterograde motility of nuclei, chloroplasts, mitochondria and secretory vesicles was suppressed. Ectopic expression of non-motile or tail-deleted ARK did not restore organelle distribution. Another prominent macroscopic phenotype of ARK mutants was the suppression of cell tip growth. We showed that this defect was attributed to the mislocalization of actin regulators, including RopGEFs; expression and forced apical localization of RopGEF3 partially rescued the growth phenotype of the ARK mutant. The mutant phenotypes were partially rescued by ARK homologues in Arabidopsis thaliana, suggesting the conservation of ARK functions in plants.Plant-specific kinesin ARK is identified as a major microtubule plus-end-directed transporter in Physcomitrella (moss). ARK motility-dependent tip localization of actin regulators is required for proper cell polarization and growth.
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