Journal Article

Reduction of elevated lipids and low‐density lipoprotein oxidation in serum of individuals with subclinical hypoxia and oxidative stress supplemented with lycosome formulation of docosahexaenoic acid

Kyle, Nigel H., Chalyk, Natalia E., Klochkov, Victor A., Dovgalevsky, Pavel Y., Petyaev, Ivan M.

2019

Overview

Thirty two individuals aged 40–65 years old with a moderate hyperlipidemia (serum triglycerides > 150 mg/dl and LDL from 130 to 160 mg/dl) were supplemented once daily for 30 days with a 250 mg conventional formulation of docosahexaenoic acid (DHA) without lycopene (CF‐DHA) or 250 mg of lycosome‐formulated DHA containing 7 mg of lycopene (LF‐DHA). It was shown that ingestion of CF‐DHA led to a transient increase in serum DHA level after 2 weeks of the trial, whereas LF‐DHA did not cause significant changes in serum DHA. However, there was a noticeable increase in serum eicosapentaenoic acid levels exceeding the pretreatment value by 42.8% and 39.1% after the 2nd and 4th weeks of LF‐DHA ingestion. Patients supplemented with LF‐DHA showed a significant (19.5 mg/dl, p < 0.05) decline in LDL, which was accompanied by a corresponding decrease in total serum cholesterol and a much stronger reduction in serum triglyceride levels (reduction of medians by 27.5 mg/dl). No changes in HDL were observed. LF‐DHA caused a significant decline in the serum level of malonic dialdehyde (MDA), whereas the components of LF‐DHA, lycopene and DHA, ingested as two separate formulations had a less significant effect on serum MDA. Moreover, LF‐DHA increased both the plasma oxygen transport and tissue oxygen saturation by the end of the observational period, while lycopene or DHA taken alone, or both of them co‐ingested separately had none or a much less effect on the oxygen turnover parameters. LF‐DHA caused a significant decline in serum levels of malonic dialdehyde (MAD), whereas the components of LF‐DHA—lycopene and DHA ingested as two separate or combined formulation had much smaller effect on serum MAD. Moreover, LF‐DHA increased both the plasma oxygen transport and tissue oxygen saturation at the end of observational period, although lycopene alone or lycopene co‐ingested with DHA had no or much less effect on the oxygen turnover parameters.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc
• Subject: Atherosclerosis / Bioavailability / Cardiology / Cholesterol / Consent / Docosahexaenoic acid / Eicosapentaenoic acid / Fatty acids / Formulations / Functional foods & nutraceuticals / High density lipoprotein / Homeostasis / Hyperlipidemia / Hypoxia / Ingestion / LDL oxidation / Lipids / Low density lipoprotein / Lycopene / Metabolism / Original Research / Oxidation / Oxidative stress / Oxygen / Oxygen content / Pretreatment / Reduction / Studies / triglyceride and LDL reduction / Triglycerides / Values