Journal Article

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration

Chen, Hai‐Wei, Gao, Yi‐Cheng, He, Xue‐Gang, Ma, Zhan‐Jun, Zhang, Guang‐Zhi, Liu, Ming‐Qiang, Wu, Zuo‐Long, Kang, Xue‐Wen

2021

Overview

Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral discs (IVD), leading to dysfunction and structural destruction of the IVD. Nuclear factor‐κB (NF‐κB) transcription factor has long been regarded as a pathogenic factor of IDD. Therefore, NF‐κB may be an ideal therapeutic target for IDD. As NF‐κB is a multifunctional functional transcription factor with roles in a variety of biological processes, a comprehensive understanding of the function and regulatory mechanism of NF‐κB in IDD pathology will be useful for the development of targeted therapeutic strategies for IDD, which can prevent the progression of IDD and reduce potential risks. This review discusses the role of the NF‐κB signalling pathway in the nucleus pulposus (NP) in the process of IDD to understand pathological NP degeneration further and provide potential therapeutic targets that may interfere with NF‐κB signalling for IDD therapy. Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress, and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral discs (IVD), leading to dysfunction and structural destruction of the IVD. Nuclear factor‐κB (NF‐κB) transcription factor has long been regarded as the pathogenic factor of IDD. Therefore, NF‐κB may be an ideal therapeutic target for IDD. As NF‐κB is a multifunctional functional transcription factor with roles in a variety of biological processes, a comprehensive understanding of the function and regulatory mechanism of NF‐κB in IDD pathology will be useful for the development of targeted therapeutic strategies for IDD, which can prevent the progression of IDD and reduce potential risks. This review discusses the role of the NF‐κB signalling pathway in the nucleus pulposus (NP) in the process of IDD to understand pathological NP degeneration further and provide potential therapeutic targets that may interfere with NF‐κB signalling for IDD therapy. ​

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc
• Subject: Apoptosis / Back pain / Biological activity / Cartilage / Cell cycle / Cell division / Collagen / Degeneration / Degenerative disc disease / DNA damage / Enzymes / Extracellular matrix / Homeostasis / Inflammation / intervertebral disc degeneration / Intervertebral discs / Metabolism / Mitochondrial DNA / nuclear factor‐κB / Nuclei (cytology) / Nucleus pulposus / Oxidative stress / Pathogenesis / Radiation / Regulatory mechanisms (biology) / Review / Reviews / Senescence / Signal transduction / Signaling / Spine / Telomerase / Therapeutic applications / Therapeutic targets