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A Global Gene Pool for High-Level Cephalosporin Resistance in Commensal Streptococcus Species and Streptococcus Pneumoniae
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A Global Gene Pool for High-Level Cephalosporin Resistance in Commensal Streptococcus Species and Streptococcus Pneumoniae
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A Global Gene Pool for High-Level Cephalosporin Resistance in Commensal Streptococcus Species and Streptococcus Pneumoniae
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Journal Article
A Global Gene Pool for High-Level Cephalosporin Resistance in Commensal Streptococcus Species and Streptococcus Pneumoniae
1997
Overview
Highly penicillin- and cephalosporin-resistant Streptococcus mitis and Streptococcus oralis were isolated in Spain, Hungary, and Berlin. With chromosomal DNA of these strains, resistant transformants of Streptococcus pneumoniae were obtained that expressed low-affinity variants of penicillin- binding proteins (PBPs) 2x, 1a, 2a, and 2b in different combinations, depending on the selective conditions. The transformants had cefotaxime MICs of up to 6 µg/mL, and those with a low-affinity PBP 2b were highly deficient in penicillin-induced lysis. Sequence analysis of the pbp2x genes confirmed the presence of a global gene pool of penicillin resistance determinants shared by commensal and pathogenic streptococci.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Biological and medical sciences
/ Carrier Proteins - metabolism
/ Cephalosporin Resistance - genetics
/ Cephalosporins - pharmacology
/ DNA
/ Drug Resistance, Microbial - genetics
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Humans
/ Mosaic
/ Penicillin Resistance - genetics
/ Sequence Homology, Amino Acid
/ Sequence Homology, Nucleic Acid
/ Streptococcal Infections - drug therapy
/ Streptococcal Infections - epidemiology
/ Streptococcal Infections - genetics
/ Streptococcus oralis - genetics
