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The Relationship of Tumor-infiltrating Lymphocyte Ratio with Histopathological Parameters and Effect on Survival in Colorectal Cancers
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The Relationship of Tumor-infiltrating Lymphocyte Ratio with Histopathological Parameters and Effect on Survival in Colorectal Cancers
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Journal Article
The Relationship of Tumor-infiltrating Lymphocyte Ratio with Histopathological Parameters and Effect on Survival in Colorectal Cancers
2024
Overview
IntroductionTumor lymphocyte infiltration demonstrates a positive effect on patient survival in breast cancer, melanoma, renal cell carcinoma, and lung cancer. This study aimed to elucidate the relationship between tumor-infiltrating lymphocyte (TIL) ratio and disease-free survival (DFS) and overall survival (OS) by considering localization, clinical and pathological features, microsatellite instability (MSI) status, mutation status, and demographic data.MethodPatients (n=248) diagnosed with colorectal cancer stages 1, 2, and 3 were analyzed retrospectively. Patients with an Eastern Cooperative Oncology Group performance score of <2 were excluded. Clinical characteristics, age, gender, histopathologic features, TIL ratio, and carcinoembryonic antigen (CEA) level of the patients were recorded.ResultsStage, CEA level, TIL ratio, N stage, T stage, and lymphovascular invasion were statistically significant. Early stage (p=0.019), low CEA level (p≤0.001), high TIL ratio (p=0.046), low N stage (p=0.004), low T stage (p=0.016), and absence of lymphovascular invasion (p=0.037 and p=0.046) were associated with longer DFS. Lymphovascular invasion, N stage, CEA levels, and TIL ratio were analyzed using multivariate analysis. According to the results, the hazard ratio (HR) for the TIL ratio was 1.68 (95% confidence interval (CI): 1.005-2.807; p=0.048), and the HR for the CEA level was 0.49 (95% CI: 0.293-0.846; p=0.01).ConclusionRegarding the outcomes of this research, the TIL ratio was found to be an effective indicator of DFS, confirmed via multivariate analysis to present a 32% reduction in the risk of recurrence/relapse. The TIL ratio was identified as a prognostic factor beyond the effects of stage, grade, lymphovascular invasion, CEA level, and MSI status. The current data provides substantial evidence to support the ratio’s consideration in staging guidelines.
Publisher
Galenos Publishing House,Turkish Society of Colon and Rectal Surgery
