Asset Details
Do you wish to reserve the book?
Humoral Immune Response to Tetanus-Diphtheria Vaccine Given during Extended Use of Chloroquine or Primaquine Malaria Chemoprophylaxis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Humoral Immune Response to Tetanus-Diphtheria Vaccine Given during Extended Use of Chloroquine or Primaquine Malaria Chemoprophylaxis
Do you wish to request the book?
Humoral Immune Response to Tetanus-Diphtheria Vaccine Given during Extended Use of Chloroquine or Primaquine Malaria Chemoprophylaxis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Humoral Immune Response to Tetanus-Diphtheria Vaccine Given during Extended Use of Chloroquine or Primaquine Malaria Chemoprophylaxis
1998
Overview
Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention. After 11 months of prophylaxis, adult male subjects received a tetanus-diphtheria (Td) vaccination. Prophylaxis continued 4 weeks longer. Anti-tetanus and anti-diphtheria antibody levels were measured by ELISA at baseline and at 1, 3, 7, and 14 months after Td vaccination. All groups were comparable at baseline. Immunization triggered significant increases in anti-tetanus and anti-diphtheria IgG levels over each group's pre-Td baseline levels and those of an unvaccinated control group. Geometric mean anti-tetanus titers (GMTs) in the primaquine group were significantly higher than those of the placebo group at 1, 3, and 14 months. Anti-tetanus GMTs in placebo and chloroquine groups declined over 14 months to levels comparable to those of unvaccinated controls, but levels in the primaquine group remained significantly higher than in controls.
Publisher
The University of Chicago Press,University of Chicago Press
Subject
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Antibodies, Bacterial - blood
/ Antimalarials - administration & dosage
/ Biological and medical sciences
/ Chloroquine - administration & dosage
/ Diphtheria Toxoid - immunology
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Malaria
/ Malaria - prevention & control
/ Male
/ Pharmacology. Drug treatments
/ Placebos
/ Primaquine - administration & dosage
/ Tetanus
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
