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Clonogenic long-term survival assay of HCT 116 colorectal cancer cells after treatment with the synthesized diphenyl imidazoline derivatives
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Clonogenic long-term survival assay of HCT 116 colorectal cancer cells after treatment with the synthesized diphenyl imidazoline derivatives
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Clonogenic long-term survival assay of HCT 116 colorectal cancer cells after treatment with the synthesized diphenyl imidazoline derivatives
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Journal Article
Clonogenic long-term survival assay of HCT 116 colorectal cancer cells after treatment with the synthesized diphenyl imidazoline derivatives
2018
Overview
Fourteen diphenyl imidazoline derivatives were designed, synthesized, and identified using NMR spectroscopy and high-resolution mass spectrometry. Their cytotoxicities in HCT 116 colorectal cancer cell lines were measured using a clonogenic long-term survival assay and the half-maximal cell growth inhibitory concentration (GI
50
) values were in the range 3.1–58.4 μM. As the anticancer effects of diphenyl imidazolines were reported to be caused by the inhibition of mouse double minute 2 homolog (MDM2), the inhibitory effects of the most potent derivative on MDM2 were assessed through Western blotting analysis. In silico docking experiments revealed the binding mode between this derivative and MDM2.
Publisher
Springer Netherlands,Springer Nature B.V,한국응용생명화학회
Subject
