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Novel Approaches to the Treatment of Hepatitis C Virus Infection
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Novel Approaches to the Treatment of Hepatitis C Virus Infection
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Journal Article
Novel Approaches to the Treatment of Hepatitis C Virus Infection
2000
Overview
Hepatitis C virus (HCV) has infected millions of people worldwide and emerged as a global health crisis. This review reports approaches currently being taken to combat the virus. Viral targets have received the most attention, particularly the NS3 serine protease where potent inhibitors have been described. Crystal structures of key replicative enzymes, NS3 protease, NS3 helicase, NS5B polymerase and now full-length NS3 protease-helicase, are available. More recently, targeting the host system has become of interest, particularly inhibitors of inosine monophosphate dehydrogenase. Research aimed at novel treatments for HCV disease is gathering pace and very recent developments in cell-based assay systems can only hasten the discovery of improved therapies.
Publisher
SAGE Publications,International Medical Press,Sage Publications Ltd
Subject
/ Animals
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Antiviral Agents - chemistry
/ Antiviral Agents - pharmacology
/ Biological and medical sciences
/ helicase
/ Humans
/ inosine monophosphate dehydrogenase
/ Oligonucleotides, Antisense - genetics
/ Oligonucleotides, Antisense - pharmacology
/ Pharmacology. Drug treatments
/ RNA Helicases - drug effects
/ Serine
/ Viral Nonstructural Proteins - chemistry
