Asset Details
Do you wish to reserve the book?
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
Do you wish to request the book?
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
2019
Overview
Hydrogen sulfide (H
2
S) plays important roles in metabolism and health. Its enzymatic generation from sulfur-containing amino acids (SAAs) is well characterized. However, the existence of non-enzymatic H
2
S production from SAAs, the chemical mechanism, and its biological implications remain unclear. Here we present non-enzymatic H
2
S production in vitro and in blood via a reaction specific for the SAA cysteine serving as substrate and requires coordinated catalysis by Vitamin B
6
, pyridoxal(phosphate), and iron under physiological conditions. An initial cysteine-aldimine is formed by nucleophilic attack of the cysteine amino group to the pyridoxal(phosphate) aldehyde group. Free or heme-bound iron drives the formation of a cysteine-quinonoid, thiol group elimination, and hydrolysis of the desulfurated aldimine back to pyridoxal(phosphate). The reaction ultimately produces pyruvate, NH
3
, and H
2
S. This work highlights enzymatic production is inducible and robust in select tissues, whereas iron-catalyzed production contributes underappreciated basal H
2
S systemically with pathophysiological implications in hemolytic, iron overload, and hemorrhagic disorders.
Jie Yang et al. show the non-enzymatic production of hydrogen sulfide from sulfur-containing amino acids (SAA) in vitro and in blood. They find that the reaction uses SAA cysteine as a substrate, and requires coordinated catalysis by Vitamin B6 and iron, all under physiological conditions.
