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Utility of 18F-Fluorodeoxyglucose Positron Emission Tomography in Inflammatory Rheumatism, Particularly Polymyalgia Rheumatica: A Retrospective Study of 222 PET/CT
by
Soubrier, Martin
, Valla, Clemence
, Cougoul, Arnaud
, Cachin, Florent
, Mathieu, Sylvain
, Amat, Julie
, Olagne, Louis
, Descamps, Lucie
, Merlin, Charles
, Bouvet, Clément
, Barres, Bertrand
, Kelly, Antony
, Chanchou, Marion
, Flaus, Anthime
, Molnar, Ioana
, Aumaitre, Olivier
in
18F-FDG PET/CT
/ bursa
/ Drug dosages
/ Inflammatory diseases
/ inflammatory rheumatism
/ Internal medicine
/ Kruskal-Wallis test
/ Life Sciences
/ Liver
/ Medicine
/ Older people
/ Patients
/ PMR
/ Rheumatic diseases
/ Rheumatism
/ Steroids
/ SUVmax
/ Tomography
/ uptake scores
2020
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Utility of 18F-Fluorodeoxyglucose Positron Emission Tomography in Inflammatory Rheumatism, Particularly Polymyalgia Rheumatica: A Retrospective Study of 222 PET/CT
by
Soubrier, Martin
, Valla, Clemence
, Cougoul, Arnaud
, Cachin, Florent
, Mathieu, Sylvain
, Amat, Julie
, Olagne, Louis
, Descamps, Lucie
, Merlin, Charles
, Bouvet, Clément
, Barres, Bertrand
, Kelly, Antony
, Chanchou, Marion
, Flaus, Anthime
, Molnar, Ioana
, Aumaitre, Olivier
in
18F-FDG PET/CT
/ bursa
/ Drug dosages
/ Inflammatory diseases
/ inflammatory rheumatism
/ Internal medicine
/ Kruskal-Wallis test
/ Life Sciences
/ Liver
/ Medicine
/ Older people
/ Patients
/ PMR
/ Rheumatic diseases
/ Rheumatism
/ Steroids
/ SUVmax
/ Tomography
/ uptake scores
2020
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Utility of 18F-Fluorodeoxyglucose Positron Emission Tomography in Inflammatory Rheumatism, Particularly Polymyalgia Rheumatica: A Retrospective Study of 222 PET/CT
by
Soubrier, Martin
, Valla, Clemence
, Cougoul, Arnaud
, Cachin, Florent
, Mathieu, Sylvain
, Amat, Julie
, Olagne, Louis
, Descamps, Lucie
, Merlin, Charles
, Bouvet, Clément
, Barres, Bertrand
, Kelly, Antony
, Chanchou, Marion
, Flaus, Anthime
, Molnar, Ioana
, Aumaitre, Olivier
in
18F-FDG PET/CT
/ bursa
/ Drug dosages
/ Inflammatory diseases
/ inflammatory rheumatism
/ Internal medicine
/ Kruskal-Wallis test
/ Life Sciences
/ Liver
/ Medicine
/ Older people
/ Patients
/ PMR
/ Rheumatic diseases
/ Rheumatism
/ Steroids
/ SUVmax
/ Tomography
/ uptake scores
2020
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Utility of 18F-Fluorodeoxyglucose Positron Emission Tomography in Inflammatory Rheumatism, Particularly Polymyalgia Rheumatica: A Retrospective Study of 222 PET/CT
Journal Article
Utility of 18F-Fluorodeoxyglucose Positron Emission Tomography in Inflammatory Rheumatism, Particularly Polymyalgia Rheumatica: A Retrospective Study of 222 PET/CT
2020
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Overview
Purpose: The objective of this study was to evaluate periarticular FDG uptake scores from 18F-FDG-PET/CT to identify polymyalgia rheumatica (PMR) within a population presenting rheumatic diseases.Methods: A French retrospective study from 2011 to 2015 was conducted. Patients who underwent 18F-FDG-PET/CT for diagnosis or follow-up of a rheumatism or an unexplained biological inflammatory syndrome were included. Clinical data and final diagnosis were reviewed. Seventeen periarticular sites were sorted by a visual reading enabling us to calculate two scores: mean FDG visual uptake score, number of sites with significant uptake same as that or higher than liver uptake intensity and by a semi-quantitative analysis using mean maximum standardized uptake value (SUVmax). Optimal cutoffs of visual score and SUVmax to diagnose PMR were determined using receiver operating characteristics curves.Results: Among 222 18F-FDG PET/CT selected for 215 patients, 161 18F-FDG PET/CT were performed in patients who presented inflammatory rheumatism as a final diagnosis (of whom 57 PMR). The presence of at least three sites with significant uptake identified PMR with a sensitivity of 86% and a specificity of 85.5% (AUC 0.872, 95% CI [0.81–0.93]). The mean FDG visual score cutoff to diagnose a PMR was 0.765 with a sensitivity of 82.5% and a specificity of 75.8% (AUC 0.854; 95% CI [0.80–0.91]). The mean SUVmax cutoff to diagnose PMR was 2.168 with a sensitivity of 77.2% and a specificity of 77.6% (AUC 0.842; 95% CI [0.79–0.89]).Conclusions: This study suggests that 18F-FDG PET/CT had good performances to identify PMR within a population presenting rheumatic diseases.
Publisher
Frontiers Media SA,Frontiers media,Frontiers Media S.A
Subject
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