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Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
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Journal Article
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
2010
Overview
Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease. Both native and custom TALE-nuclease fusions direct DNA double-strand breaks to specific, targeted sites.
Publisher
Genetics Society of America
Subject
/ Deoxyribonucleases, Type II Site-Specific - chemistry
/ Deoxyribonucleases, Type II Site-Specific - genetics
/ Deoxyribonucleases, Type II Site-Specific - metabolism
/ DNA
/ DNA-Binding Proteins - chemistry
/ DNA-Binding Proteins - metabolism
/ Enzymes
/ Genetics
/ Proteins
/ Reagents
/ Recombinant Fusion Proteins - chemistry
/ Recombinant Fusion Proteins - metabolism
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Yeast
