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Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro
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Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro
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Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro
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Journal Article
Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro
2009
Overview
Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on chemokine receptor expression, CXCR3
+
CCR4
-
CD4
+
T cells as Th1-type cells were investigated its capacity in monocyte-derived dendritic cell (DC) maturation and polarization, and induction of antigen specific cytotoxic T lymphocytes (CTL)
in vitro
. The levels of IL-4, IL-5 and IL-10 were decreased to the basal level compared with high production of IFN-γ, TNF-α, and IL-2 in CXCR3
+
CCR4
-
CD4
+
T cells stimulated with anti-CD3 and anti-CD28 antibodies. Co-incubation of activated CD4
+
or CXCR3
+
CCR4
-
CD4
+
T cells with DC (CD4
+
/DC or CXCR3
+
CD4
+
/DC, respectively) particularly up-regulated IL-12 and CD80 expression compared with DC matured with TNF-α and LPS (mDC). Although there was no significant difference between the effects of the CXCR3
+
CCR4
-
CD4
+
and CD4
+
T cells on DC phenotype expression, CXCR3
+
CD4
+
/DC in CTL culture were able to expand number of CD8
+
T cells and increased frequencies of IFN-γ secreting cells and overall cytolytic activity against tumor antigen WT-1. These results demonstrated that the selective addition of CXCR3
+
CCR4
-
CD4
+
T cells to CTL cultures could enhance the induction of CTLs by DC
in vitro
, and implicated on a novel strategy for adoptive T cell therapy.
Publisher
Nature Publishing Group UK,Springer Nature B.V,Korean Society of Medical Biochemistry and Molecular Biology,생화학분자생물학회
