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Cloning, characterization, and expression of a novel member of proteasomal subunits gene in turbot, Scophthalmus maximus
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Cloning, characterization, and expression of a novel member of proteasomal subunits gene in turbot, Scophthalmus maximus
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Cloning, characterization, and expression of a novel member of proteasomal subunits gene in turbot, Scophthalmus maximus
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Journal Article
Cloning, characterization, and expression of a novel member of proteasomal subunits gene in turbot, Scophthalmus maximus
2015
Overview
The proteasome is a large, polymeric protease complex responsible for the degradation of intracellular pro- teins and generation of peptides that bind to class I major histocompatibility complex （MHC） molecules. This study identified a new member of proteasomal subunits in turbots （Scophthalrnus rnaxirnus）. The full- length cDNA sequence of turbot proteasomal subunit was obtained. Sequence analysis indicated that its primary structure is highly similar to that of LMP7 from other vertebrates. The relationship between the turbot LMP7 expression and immune responses to pathogen infection was reported. Quantitative reverse transcriptase polymerase chain reaction showed that LMPTwas expressed differently in various tissues, with higher expression in the spleen, liver, muscle, and skin. The LMP7 expression was the highest at 96 h after challenge with lymphocyctis disease virus （LCDV） and at 12 h after challenge with Vibrio anguillarurn in the turbot liver, kidney, and spleen. Furthermore, the LMP7 expression distinctly increased in turbot kidney cells at 24 h after challenge with V. anguillarurn and at 96 h after challenge with LCDV. These results indicate that the turbot LMP7 protein participates in immune responses and may play a significant role in the immune process.
Publisher
The Chinese Society of Oceanography,Springer Nature B.V,Tianjin Bohai Sea Fisheries Research Institute, Bohai Sea Fisheries Research Center of Chinese Academy of Fishery Sciences, Tianjin 300457, China%Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai 200065, China
