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Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia
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Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia
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Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia
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Journal Article
Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia
2016
Overview
Abstract
Study Objectives:
To examine the association between periodic limb movements in sleep (PLMS) and change in selected aspects of cognition in community-dwelling older men.
Methods:
We studied 2,636 older men without dementia who underwent in-home polysomnography with measurement of the periodic limb movement index (PLMI) and periodic limb movement arousal index (PLMAI) using piezoelectric sensors. Random-effects models and logistic regression were used to examine the association between PLMI, PLMAI, and 3- to 4-y change in cognition.
Results:
After multivariable adjustment, men with a high PLMI had greater decline on the Trail Making Test – Part B (P trend = 0.02); those with a PLMI ≥ 30 were 48% more likely (odds ratio = 1.48, 95% confidence interval = 1.05–2.07) to experience the development of significant cognitive impairment (≥ 1 SD above mean change). Further adjustment for sleep efficiency, nocturnal hypoxemia, or dopaminergic medication use and analysis among men without Parkinson disease (n = 2,607) showed similar findings. No significant association was found for PLMAI or for Modified Mini-Mental State Examination scores.
Conclusions:
Among older men without dementia, higher PLMS frequency was associated with greater decline in cognition, particularly in executive function.
Publisher
Oxford University Press,Associated Professional Sleep Societies, LLC
