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ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primates

by Thomas, Rasmi , Mutascio, Simona , Rosado, Lorean , Ferrari, Guido , Rao, Mangala , Bergmann-Leitner, Elke S. , Jha, Shalini , Zemil McCrea, Michelle , Paquin-Proulx, Dominic , Carmen, Joshua M. , Kim, Jiae , Yates, Adam , Pollara, Justin , Polonis, Victoria , Matyas, Gary R. , Alving, Ryan , Trinh, Hung V. , Bolton, Jessica S. , Shrivastava, Shikha , Nguyen, Phuong , Ake, Julie A. , Swafford, Isabella , Peachman, Kristina K. , Rahman, Mohammad Arif , Nettere, Danielle , Wieczorek, Lindsay , Kundu, Gautam , Yum, Lauren , Beck, Zoltan , Morrison, Elaine , Machmach, Kawthar , Misicka, Elina , Jobe, Ousman , Basu, Shraddha , Alving, Carl R. , Franchini, Genoveffa , Haynes, Barton F.

in 631/250 / 692/699 / Acquired immune deficiency syndrome / Adjuvants / AIDS / Aluminum / Animals / Antibodies / Antigens / Biomedical and Life Sciences / Biomedicine / Blood / Bone marrow / Clinical trials / HIV / Human immunodeficiency virus / Immune response / Immunization / Immunogenicity / Infectious Diseases / Lymphocytes / Medical Microbiology / Peptides / Proteins / Public Health / Vaccine / Vaccines / Virology

2025

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2025

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2025

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Journal Article

ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primates

Thomas, Rasmi,

Mutascio, Simona,

Rosado, Lorean,

Ferrari, Guido,

Rao, Mangala,

Bergmann-Leitner, Elke S.,

Jha, Shalini,

Zemil McCrea, Michelle,

Paquin-Proulx, Dominic,

Carmen, Joshua M.,

Kim, Jiae,

Yates, Adam,

Pollara, Justin,

Polonis, Victoria,

Matyas, Gary R.,

Alving, Ryan,

Trinh, Hung V.,

Bolton, Jessica S.,

Shrivastava, Shikha,

Nguyen, Phuong,

Ake, Julie A.,

Swafford, Isabella,

Peachman, Kristina K.,

Rahman, Mohammad Arif,

Nettere, Danielle,

Wieczorek, Lindsay,

Kundu, Gautam,

Yum, Lauren,

Beck, Zoltan,

Morrison, Elaine,

Machmach, Kawthar,

Misicka, Elina,

Jobe, Ousman,

Basu, Shraddha,

Alving, Carl R.,

Franchini, Genoveffa,

Haynes, Barton F.

2025

Overview

Adjuvants play an important role in modulating antigen-specific immune responses. We conducted a comparative adjuvant immunogenicity study in Rhesus macaques using HIV-1 subtype B gp120 envelope protein, B.63521, formulated with aluminum hydroxide gel (AH), or a family of liposomal adjuvants known as Army Liposome Formulation (ALF). ALF comprises saturated phospholipids, cholesterol, and monophosphoryl lipid A. Inclusion of QS-21 or adsorption of the antigen to AH, followed by the addition of ALF, generates ALFQ and ALFA, while inclusion of both immunostimulants generates ALFQA. Priming with canarypox vector ALVAC, followed by boosting with ALVAC and gp120 formulated with each of the four adjuvants, resulted in ALFQ and ALFQA outperforming AH and ALFA vaccine formulations with a high frequency of antigen-specific plasma cells in the bone marrow, robust antibodies, and Env-specific polyfunctional CD8 + T cell responses. Transcriptomic analyses revealed upregulation of antiviral and innate immune pathways, thus highlighting ALFQ as a highly potent adjuvant.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/250

/ 692/699

/ Acquired immune deficiency syndrome

/ Adjuvants

/ AIDS

/ Aluminum

/ Animals