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Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum
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Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum
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Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum
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Journal Article
Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum
2013
Overview
The effect of Cuscuta chinensis extract on the rabbit penile corpus cavernosum （PCC） was evaluated in the present study. Penises obtained from healthy male New Zealand white rabbits （2.5-3.0 kg） were precontracted with phenylephrine （Phe, 10 pmol I^-1） and then treated with various concentrations of Cuscuta chinensis extract （1, 2, 3, 4 and 5 mg ml^-1）. The change in penile tension was recorded, and cyclic nucleotides in the PCC were measured by radioimmunoassay （RIA）. The interaction between Cuscuta chinensis and sildenafil was also evaluated. The result indicated that the PCC relaxation induced by Cuscuta chinensis extract was concentration-dependent. Pre-treatment with an nitric oxide synthase （NOS） inhibitor （No〉 nitro-L-arginine-methyl ester, L-NAME）, a guanylyl cyclase inhibitor （1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-l-one, ODQ）, or a protein kinase A inhibitor （KT 5720） did not completely inhibit the relaxation. Incubation of penile cavernous tissue with the Cuscuta chinensis extract significantly increased cyclic guanosine monophosphate （cGMP） and cyclic adenosine monophosphate （cAMP） in the PCC. Moreover, the Cuscuta chinensis extract significantly enhanced sildenafil-induced PCC relaxation. In conclusion, the Cuscuta chinensis extract exerts a relaxing effect on penile cavernous tissue in part by activating the NO-cGMP pathway, and it may improve erectile dysfunction （ED）, which does not completely respond to sildenafil citrate.
Publisher
Medknow Publications & Media Pvt. Ltd,Nature Publishing Group
Subject
/ Enzyme Inhibitors - pharmacology
/ Erectile Dysfunction - drug therapy
/ Male
/ Muscle Relaxation - drug effects
/ Muscle, Smooth - drug effects
/ NG-Nitroarginine Methyl Ester - pharmacology
/ Original
/ Penile Erection - drug effects
/ Plant Extracts - pharmacology
/ Rabbits
/ 一氧化氮合成酶
/ 提取物
/ 新西兰白兔
/ 松弛
/ 枸橼酸西地那非
/ 浓度依赖性
/ 菟丝子
/ 阴茎海绵体
