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Genetic Prediction of Erectile Dysfunction Caused by Statins Among Malaysian Cardiac Patients
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Genetic Prediction of Erectile Dysfunction Caused by Statins Among Malaysian Cardiac Patients
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Journal Article
Genetic Prediction of Erectile Dysfunction Caused by Statins Among Malaysian Cardiac Patients
2025
Overview
Erectile dysfunction (ED) is a significant disorder commonly found in patients with cardiovascular diseases and diabetes mellitus. Recent updates have indicated that statins may also contribute to an increased risk of ED. This cross-sectional genetic study involved 246 cardiac patients attending normal visits at Hospital Universiti Sains Malaysia (USM) Kubang Kerian outpatient clinics. The patients were categorized into four groups: statins with ED (group 1), statins without ED (group 2), diabetes with statin without ED (group 3), and healthy patients without diabetes mellitus and statin use (group 4). Six genes were hypothesized to influence ED: CYP19A1, CYP17A1, SIM1, TP53, NR2F2, and NOS3, with different polymorphisms and variants investigated in this study. Overall, statin therapy was found to have a negative impact on ED by affecting NR2F2-AS1 and NOS3. However, atorvastatin showed varying effects on ED for all genes, with the highest impact observed with CYP17A1 and the lowest with CYP19A1. In conclusion, this study revealed novel findings related to genetic factors influencing ED in Malaysian males during statin use.
Publisher
MDPI AG,Multidisciplinary Digital Publishing Institute (MDPI)
Subject
/ Aged
/ Diabetes
/ Enzymes
/ Erectile Dysfunction - chemically induced
/ Erectile Dysfunction - epidemiology
/ Erectile Dysfunction - genetics
/ Genes
/ Genetic Predisposition to Disease
/ Humans
/ Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
/ Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
/ Male
/ Males
/ Nitric Oxide Synthase Type III - genetics
/ Polymorphism, Single Nucleotide
/ Statins
