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The Number of Centers in a Multicenter Clinical Study: Effects on Statistical Power
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The Number of Centers in a Multicenter Clinical Study: Effects on Statistical Power
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Journal Article
The Number of Centers in a Multicenter Clinical Study: Effects on Statistical Power
2000
Overview
In the pharmaceutical industry it is often important to ensure fast patient enrollment. A common practice to speed up patient enrollment is to use more clinical centers. One of the concerns regarding this practice is that increasing the total number of centers to a certain degree may decrease the statistical efficiency of treatment comparisons. This is mainly because a study with too many clinical centers usually includes quite a few small centers and very often they do not have enough patients to represent all treatment groups. These small centers often carry little information on treatment differences. This paper utilizes a statistical model to quantify the relationship between statistical efficiency and the number of centers under typical clinical trial settings. Results in this paper provide useful statistical knowledge in choosing the number of clinical centers when planning multicenter studies.
Publisher
SAGE Publications,Pergamon Press,Springer Nature B.V
