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KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors
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KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors
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Journal Article
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors
2020
Overview
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands. Directly impacting NK cell function,
polymorphism associates with infection control and multiple autoimmune and pregnancy syndromes. Here we analyze
diversity of 241 individuals from five groups of Iranians. These five populations represent Baloch, Kurd, and Lur, together comprising 15% of the ethnically diverse Iranian population. We identified 159
alleles, including 11 not previously characterized. We also identified 170 centromeric and 94 telomeric haplotypes, and 15 different
haplotypes carrying either a deletion or duplication encompassing one or more complete
genes. As expected, comparing our data with those representing major worldwide populations revealed the greatest similarity between Iranians and Europeans. Despite this similarity we observed higher frequencies of
in Iran than any other population, and the highest frequency of HLA-B
51, a Bw4-containing allotype that acts as a strong educator of
NK cells. Compared to Europeans, the Iranians we studied also have a reduced frequency of
, which encodes an allotype that is not expressed at the NK cell surface. Concurrent with the resulting high frequency of strong viable interactions between inhibitory KIR and polymorphic HLA class I, the majority of
haplotypes characterized do not express a functional activating receptor. By contrast, the most frequent
haplotype in Iran expresses only one functional inhibitory KIR and the maximum number of activating KIR. This first complete, high-resolution, characterization of the
locus of Iranians will form a valuable reference for future clinical and population studies.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Genes
/ Genomics
/ Histocompatibility antigen HLA
/ Histocompatibility Antigens Class I - genetics
/ Histocompatibility Antigens Class I - immunology
/ Humans
/ Iran
/ Killer cell immunoglobulin-like receptors
/ Killer Cells, Natural - immunology
/ KIR
/ Ligands
/ NK cells
/ Polymorphism, Genetic - genetics
/ Polymorphism, Genetic - immunology
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