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The Singapore National Precision Medicine Strategy

by Karnani, Neerja , Tai, E. Shyong , Liu, Jianjun , Tan, Tin Wee , Sung, Joseph Jao-Yiu , Leong, Khai Pang , Krishnaswamy, Pavitra , Chia, Irenaeus , Goh, Liuh Ling , Low, Doreen , Virabhak, Suchin , Bertin, Nicolas , Chua, Chee Yong , Ho, Clarissa , Wong, Eleanor , Prabhakar, Shyam , Yong, Jacklyn , Koh, Mingshi , Maurer-Stroh, Sebastian , Cheong, Wei Yang , Verma, Chandra Shekhar , Chua, Raymond , Seow, Shih Wee , Cheng, Ching-Yu , Thien, Kwee Eng , Chin, Calvin Woon Loong , Mak, Kenneth , Goh, Rick Siow Mong , Lim, Tit Meng , Tirado-Magallanes, Roberto , Lee, Jimmy , Seck, Yee Kwang , Goh, Khean Teik , Sim, Xueling , Tan, Patrick , Chai, Jin-Fang , Hebrard, Maxime , Zheng, Weiling , Davila, Sonia , Bellis, Claire , Tong, Philomena Mei Lin , Ban, Kenneth Hon Kim , Chambers, John C. , Lim, Weng Khong , Wong, Tien Yin , Gluckman, Peter D.

in 631/208/457 / 692/700/459/1748 / Aging / Agriculture / Animal Genetics and Genomics / Asia / Asian people / Biobanks / Biomedical and Life Sciences / Biomedicine / Cancer Research / Delivery of Health Care / Diabetes / Disease / Disease detection / Economic analysis / Electronic health records / Gene Function / Genetics / Genomic analysis / Health care / Health care expenditures / Health risk assessment / Human Genetics / Humans / Multiculturalism & pluralism / Perspective / Precision medicine / Precision Medicine - methods / Singapore

2023

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2023

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Journal Article

The Singapore National Precision Medicine Strategy

Karnani, Neerja,

Tai, E. Shyong,

Liu, Jianjun,

Tan, Tin Wee,

Sung, Joseph Jao-Yiu,

Leong, Khai Pang,

Krishnaswamy, Pavitra,

Chia, Irenaeus,

Goh, Liuh Ling,

Low, Doreen,

Virabhak, Suchin,

Bertin, Nicolas,

Chua, Chee Yong,

Ho, Clarissa,

Wong, Eleanor,

Prabhakar, Shyam,

Yong, Jacklyn,

Koh, Mingshi,

Maurer-Stroh, Sebastian,

Cheong, Wei Yang,

Verma, Chandra Shekhar,

Chua, Raymond,

Seow, Shih Wee,

Cheng, Ching-Yu,

Thien, Kwee Eng,

Chin, Calvin Woon Loong,

Mak, Kenneth,

Goh, Rick Siow Mong,

Lim, Tit Meng,

Tirado-Magallanes, Roberto,

Lee, Jimmy,

Seck, Yee Kwang,

Goh, Khean Teik,

Sim, Xueling,

Tan, Patrick,

Chai, Jin-Fang,

Hebrard, Maxime,

Zheng, Weiling,

Davila, Sonia,

Bellis, Claire,

Tong, Philomena Mei Lin,

Ban, Kenneth Hon Kim,

Chambers, John C.,

Lim, Weng Khong,

Wong, Tien Yin,

Gluckman, Peter D.

2023

Overview

Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic–phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world’s population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption. This Perspective article discusses Singapore’s efforts to implement a National Precision Medicine Strategy through the integration of genomic, clinical and lifestyle data of up to one million Singaporean individuals.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

631/208/457

/ 692/700/459/1748

/ Aging

/ Agriculture

/ Animal Genetics and Genomics

/ Asia

/ Asian people