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The milestone for preventing post-ERCP pancreatitis using novel simplified predictive scoring system: a propensity score analysis
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The milestone for preventing post-ERCP pancreatitis using novel simplified predictive scoring system: a propensity score analysis
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Journal Article
The milestone for preventing post-ERCP pancreatitis using novel simplified predictive scoring system: a propensity score analysis
2021
Overview
BackgroundPost-ERCP pancreatitis (PEP) with trans-papillary approach remains a major issue, and the multi-factorial etiology can lead to the development of unpredictable PEP. Therefore, the early identification of PEP is highly desirable to assist with the health cost containment, the reduction in unnecessary admissions, earlier appropriate primary care, and intensive care for preventing progression of severe pancreatitis. This study aimed to establish a simplified predictive scoring system for PEP.MethodsBetween January 1, 2012, and December 31, 2019, 3362 consecutive trans-papillary ERCP procedures were retrospectively analyzed. Significant risk factors were extracted by univariate, multivariate, and propensity score analyses, and the probability of PEP in the combinations of each factor were quantified using propensity score analysis. The results were internally validated using bootstrapping resampling.ResultsIn the scoring system with four stratifications using combinations of only five extracted risk factors, the very high-risk group showed 28.79% (95% confidence interval [CI], 18.30%–41.25%; P < 0.001) in the predicted incidence rate of PEP, and 9.09% (95% CI, 3.41%–18.74%; P < 0.001) in that of severe PEP; although the adjusted prevalence revealed 3.74% in PEP and 0.90% in severe PEP, respectively. The prediction model had an area under the curve of 0.86 (95% CI, 0.82–0.89) and the optimism-corrected model as an internal validation had an area under the curve of 0.81 (95% CI, 0.77–0.86).ConclusionsWe established and validated a simplified predictive scoring system for PEP using five risk factors immediately after ERCP to assist with the early identification of PEP.
Publisher
Springer Nature B.V
