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Labeling Pathological Tau: An Important Quest for the Unknown
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Labeling Pathological Tau: An Important Quest for the Unknown
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Journal Article
Labeling Pathological Tau: An Important Quest for the Unknown
2016
Overview
[...]the specificity of putative biomarkers has not reach a desirable level of certainty for the diagnosis of AD (Olsson et al., 2016). [...]due to the low invasiveness and promising results already obtained, most research efforts have been re-directed to develop selective molecules that facilitate the imaging of pathological proteins in living neurons and individuals. [...]this study demonstrated, for the first time, that pFTAA detects pathological tau in living neurons, becoming a valuable tool to assess compounds that target the aggregation and/or promote the disaggregation of pathological tau in cultured neurons, including iPSC-derived neurons from tauopathy patients. [...]studies that contribute to define the structural characteristics and temporal accumulation of pathological tau species and the cellular response to these species will contribute to the development of better diagnostic tools.
