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Journal Article
MALDI imaging mass spectrometry: molecular snapshots of biochemical systems
2007
Overview
Matrix-assisted laser desorption/ionization (
MALDI
) imaging mass spectrometry (IMS) is emerging as a powerful tool for investigating the distribution of molecules within biological systems through the direct analysis of thin tissue sections. Unique among imaging methods,
MALDI
-IMS can determine the distribution of hundreds of unknown compounds in a single measurement. We discuss the current state of the art of
MALDI
-IMS along with some recent applications and technological developments that illustrate not only its current capabilities but also the future potential of the technique to provide a better understanding of the underlying molecular mechanisms of biological processes.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Developmental Biology - methods
/ Lasers
/ Methods
/ Pharmaceutical Preparations - metabolism
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - trends
