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Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

by Su, Yi , Mez, Jesse , Peskind, Elaine R. , Tripodis, Yorghos , Luo, Ji , Marek, Kenneth L. , Barr, William B. , Katz, Douglas I. , Johnson, Keith , Rabinovici, Gil , Turner, Robert W. , McKee, Ann C. , Chen, Kewei , Wethe, Jennifer V. , Cummings, Jeffrey L. , Reiman, Eric M. , Dodick, David W. , Shenton, Martha E. , Protas, Hillary , Banks, Sarah J. , Palmisano, Joseph N. , Adler, Charles H. , Au, Rhoda , Daneshvar, Daniel H. , Alosco, Michael L. , Balcer, Laura J. , McClean, Michael D. , Bernick, Charles , Coleman, Michael J. , Stern, Robert A.

in Alzheimer's disease / American football / Asymptomatic / Biomarkers / Brain damage / Brain Injuries, Traumatic - complications / Brain research / Carbolines / Chronic traumatic encephalopathy / Chronic Traumatic Encephalopathy - diagnostic imaging / Chronic Traumatic Encephalopathy - pathology / College sports / CTE / Disease / Encephalopathy / FDA approval / flortaucipir / Football / Football - injuries / Humans / Male / Middle Aged / Neuroimaging / Pathology / PET / Positron emission tomography / Positron emission tomography (PET) / Professional players / Regions / Soccer / Tau / tau Proteins / Tomography / Trauma / Traumatic brain injury / Uptake / Womens health

2024

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Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

2024

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Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

2024

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Journal Article

Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

Su, Yi,

Mez, Jesse,

Peskind, Elaine R.,

Tripodis, Yorghos,

Luo, Ji,

Marek, Kenneth L.,

Barr, William B.,

Katz, Douglas I.,

Johnson, Keith,

Rabinovici, Gil,

Turner, Robert W.,

McKee, Ann C.,

Chen, Kewei,

Wethe, Jennifer V.,

Cummings, Jeffrey L.,

Reiman, Eric M.,

Dodick, David W.,

Shenton, Martha E.,

Protas, Hillary,

Banks, Sarah J.,

Palmisano, Joseph N.,

Adler, Charles H.,

Au, Rhoda,

Daneshvar, Daniel H.,

Alosco, Michael L.,

Balcer, Laura J.,

McClean, Michael D.,

Bernick, Charles,

Coleman, Michael J.,

Stern, Robert A.

2024

Overview

INTRODUCTION Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same‐age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES). RESULTS Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups. DISCUSSION Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.

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Publisher

John Wiley & Sons, Inc,John Wiley and Sons Inc

Subject

/ Brain Injuries, Traumatic - complications

/ Brain research