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Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer

by Hiroaki Iwamoto , Yuta Takezawa , Shingo Itai , Yoshimichi Sai , Kouji Izumi , Hiroshi Yaegashi , Atsushi Mizokami , Yukio Suga , Tsutomu Shimada , Ryo Matsushita , Yusuke Shimura

in Aged / Aged, 80 and over / Anemia / Antineoplastic Agents / Blood / Cancer therapies / Castration / Chemotherapy / Docetaxel / Drug Administration Schedule / Drug dosages / Humans / Leukopenia / Male / Middle Aged / Neutropenia / Patients / Prostate cancer / Prostate-specific antigen / Prostatic Neoplasms, Castration-Resistant / Regression analysis / Response rates / Risk factors / Side effects / Toxicity

2020

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Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer

by Hiroaki Iwamoto , Yuta Takezawa , Shingo Itai , Yoshimichi Sai , Kouji Izumi , Hiroshi Yaegashi , Atsushi Mizokami , Yukio Suga , Tsutomu Shimada , Ryo Matsushita , Yusuke Shimura

2020

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Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer

by Hiroaki Iwamoto , Yuta Takezawa , Shingo Itai , Yoshimichi Sai , Kouji Izumi , Hiroshi Yaegashi , Atsushi Mizokami , Yukio Suga , Tsutomu Shimada , Ryo Matsushita , Yusuke Shimura

2020

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Journal Article

Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer

Hiroaki Iwamoto,

Yuta Takezawa,

Shingo Itai,

Yoshimichi Sai,

Kouji Izumi,

Hiroshi Yaegashi,

Atsushi Mizokami,

Yukio Suga,

Tsutomu Shimada,

Ryo Matsushita,

Yusuke Shimura

2020

Overview

Background: The tolerability of 2-weekly docetaxel at 25-35 mg/m2 for castration-resistant prostate cancer (CRPC) has not been fully evaluated. The aim of this study was to evaluate its tolerability compared to 3-weekly docetaxel at 60-75 mg/m2 in patients with CRPC. Patients and Methods: In this retrospective study, data were compared with respect to efficacy and safety between 2-weekly and 3-weekly docetaxel regimens in patients with CRPC. Results: Time to treatment failure and prostate-specific antigen (PSA) response rate did not differ significantly between the two regimens. Compared to 3-weekly administration, incidence of severe leukopenia and febrile neutropenia was significantly lower (p<0.05), and relative dose intensity was significantly higher (p<0.05) for the 2-weekly schedule. Docetaxel dosage and PSA response were identified as independent risk factors for severe leukopenia. Conclusion: Two-weekly treatment seems better tolerated than three-weekly treatment in Japanese patients with CRPC.

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Publisher

Anticancer Research USA Inc,International Institute of Anticancer Research

Subject

Aged

/ Aged, 80 and over

/ Anemia

/ Antineoplastic Agents

/ Blood

/ Cancer therapies

/ Castration