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Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/ Bovine Reassortant Rotavirus Vaccine
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Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/ Bovine Reassortant Rotavirus Vaccine
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Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/ Bovine Reassortant Rotavirus Vaccine
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Journal Article
Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/ Bovine Reassortant Rotavirus Vaccine
2004
Overview
A quadrivalent precursor to the pentavalent rotavirus vaccine candidate RotaTeq was evaluated in a 3-dose, 439-subject study. To determine immunogenicity, the quantity of rotavirus immunoglobulin A (IgA) in stool specimens obtained, at 1 of 10 study sites, from 37 placebo and 37 vaccine recipients was measured. None of the placebo recipients showed a clinically important (⩾3-fold) increase in stool rotavirus IgA, whereas 31 vaccine recipients showed an increase after at least 1 dose of vaccine. In total, 16, 19, and 15 vaccine recipients had increases after 1, 2, and 3 doses, respectively, indicating that a 3-dose regimen increased the immune response elicited by this vaccine.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Antibodies, Viral - analysis
/ Biological and medical sciences
/ Cattle
/ Dosage
/ Dose-Response Relationship, Immunologic
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Infant
/ Placebos
/ Reassortant Viruses - immunology
/ Rotavirus Infections - immunology
/ Rotavirus Infections - prevention & control
/ Rotavirus Vaccines - administration & dosage
/ Rotavirus Vaccines - immunology
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
/ Vaccines, Attenuated - administration & dosage
/ Vaccines, Attenuated - immunology
/ Virology
/ Viruses
