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Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis

by Vazquez, Sara E , Mandel-Brehm, Caleigh , Kryzer, Thomas J , Zorn, Kelsey C , Khan, Lillian M , Bledsoe, Ian O , Pittock, Sean J , Dubey, Divyanshu , Tran, Baouyen , Sample, Hannah A , Lennon, Vanda A , DeRisi, Joseph L , Wilson, Michael R , McKeon, Andrew , O’Donovan, Brian D , Pleasure, Samuel J

in Adult / Aged / Antibodies / Antigens / Ataxia / Autoantibodies / Autoantibodies - analysis / Brain - immunology / Carrier Proteins - immunology / Case reports / Cell Surface Display Techniques / Encephalitis / Encephalitis - epidemiology / Encephalitis - immunology / Epidemiology / Hashimoto Disease - epidemiology / Hashimoto Disease - immunology / Humans / Immunoassay / Immunoglobulin G / Immunoglobulins / Male / Middle Aged / Minnesota - epidemiology / Multiple sclerosis / NMR / Nuclear magnetic resonance / Paraneoplastic Syndromes, Nervous System - immunology / Patients / Phage display / Prevalence / Proteins / Seminoma / Seminoma - complications / Testicular Neoplasms - complications / Tumors / Vertigo

2019

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Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis

2019

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Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis

2019

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Journal Article

Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis

Vazquez, Sara E,

Mandel-Brehm, Caleigh,

Kryzer, Thomas J,

Zorn, Kelsey C,

Khan, Lillian M,

Bledsoe, Ian O,

Pittock, Sean J,

Dubey, Divyanshu,

Tran, Baouyen,

Sample, Hannah A,

Lennon, Vanda A,

DeRisi, Joseph L,

Wilson, Michael R,

McKeon, Andrew,

O’Donovan, Brian D,

Pleasure, Samuel J

2019

Overview

Brain-stem and cerebellar encephalitis without the conventional anti-Ma2 autoantibody developed in a man with a history of seminoma. Phage display was used to discover IgG antibody directed at kelch-like protein 11. The same antibody was detected in 12 other men included in an archival series.

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Publisher

Massachusetts Medical Society

Subject

/ Aged

/ Ataxia

/ Autoantibodies - analysis