Journal Article

Multispectral Optoacoustic Tomography for Assessment of Crohn’s Disease Activity

Hartmann, Arndt, Strobel, Deike, Engel, Matthias, Rascher, Wolfgang, Pfeifer, Lukas, Görtz, Rüdiger S, Neufert, Clemens, Knieling, Ferdinand, Neurath, Markus F, Waldner, Maximilian J, Vetter, Marcel, Röther, Jens, Claussen, Jing, Atreya, Raja, Urich, Alexander, Kielisch, Christian, Uter, Wolfgang, Wildner, Dane, Egger, Cornelia, Hagel, Alexander, Siebler, Jürgen, Fischer, Sarah

2017

Overview

A preliminary study suggests that intestinal-wall assessment by means of noninvasive multispectral optoacoustic tomography may distinguish remission from active disease in patients with Crohn’s disease. To the Editor: In chronic inflammatory diseases, uncontrolled inflammation is associated with increased rates of hospitalization, complications, and death. Because of the potential severity of these conditions, there is an increased demand for new diagnostic approaches. 1 , 2 Multispectral optoacoustic tomography (MSOT) is a new imaging technique that permits the noninvasive quantification of hemoglobin-dependent tissue perfusion and oxygenation as surrogates of inflammation. 3 This approach uses the excitation of short-pulsed laser light with near-infrared wavelengths to induce the photoacoustic effect in targeted tissues, which results in detectable sound waves induced by thermoelastic expansion. In this single-center, cross-sectional diagnostic study (ClinicalTrials.gov number, NCT02622139), . . .

• Publisher: Massachusetts Medical Society
• Subject: Crohn Disease - diagnostic imaging / Endoscopy / Endoscopy, Gastrointestinal / Hemoglobin / Humans / Inflammation / Intestine / Intestines - diagnostic imaging / Laboratories / Medical imaging / Photoacoustic Techniques / Remission / Tomography / Tomography - methods / Ultrasonic imaging