Journal Article

An anatomic transcriptional atlas of human glioblastoma

Barnholtz-Sloan, Jill S., Olson, Eric, Cimino, Patrick J., Dee, Nick, Miller, Jeremy, Bertagnolli, Darren, Joines, Kevin, Lankerovich, Michael, Chapin, Mike, Feng, David, Gu, Guangyu, Ngo, Kiet, Sodt, Andrew, Keogh, Bart, Wohnoutka, Paul E., Bickley, Kris, Lee, Felix, Szafer, Aaron, Berens, Michael E., Butler, Stephanie, Slaughterbeck, Clifford R., Sandman, David, Jones, Allan, Datta, Suvro, Lau, Chris, Hawrylycz, Michael J., Feng, Xu, Howard, Robert, Smith, Kimberly A., Cobbs, Charles, Lemon, Tracy, Bernard, Amy, Gittleman, Haley R., Murthy, Chantal, Ng, Lydia, Dotson, Nadezhda, Mott, Erika, Stockdale, Graham, Iavarone, Antonio, Rosen, David, Shapovalova, Nadiya, Lathia, Justin D., Puchalski, Ralph B., Reding, Melissa, Rostad, Steven W., Dolbeare, Tim, Gee, Garrett, Lein, Ed, Foltz, Greg D., Yoon, Jae-Guen, Farrokhi, Farrokh R., Dang, Chinh, Marsh, Don, Gourley, Lindsey, Ebbert, Amanda, Dalley, Rachel, Uppin, Megha S., Shah, Nameeta, Phillips, John W., Boe, Andrew F., Caldejon, Shiella, Rostomily, Robert C., Long, Fuhui, Nomura, Steve R., Kuan, Leonard, Wakeman, Wayne, Riley, Zack, White, Steven J., Hejazinia, Nika, Bro

2018

Overview

Glioblastoma is the most lethal form of human brain cancer. The genomic alterations and gene expression profiles characterizing this tumor type have been widely studied. Puchalski et al. created the Ivy Glioblastoma Atlas, a freely available online resource for the research community. The atlas, a collaborative effort between bioinformaticians and pathologists, maps molecular features of glioblastomas, such as transcriptional signatures, to histologically defined anatomical regions of the tumors. The relationships identified in this atlas, in conjunction with associated databases of clinical and genomic information, could provide new insights into the pathogenesis, diagnosis, and treatment of glioblastoma. Science , this issue p. 660 An online resource maps the molecular genetic features of glioblastoma, a lethal brain cancer, to its anatomic features. Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor’s molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.

• Publisher: The American Association for the Advancement of Science
• Subject: Atlases as Topic / Brain / Brain cancer / Brain Neoplasms - genetics / Brain Neoplasms - pathology / Brain tumors / Cancer / Databases, Genetic / Diagnosis / Gene expression / Gene Expression Profiling / Gene mapping / Genomics / Glioblastoma / Glioblastoma - genetics / Glioblastoma - pathology / Glioma / Humans / Internet / Molecular chains / Pathogenesis / Prognosis / Transcription / Tumors