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The contribution of the 1H-MRS lipid signal to cervical cancer prognosis: a preliminary study
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The contribution of the 1H-MRS lipid signal to cervical cancer prognosis: a preliminary study
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Journal Article
The contribution of the 1H-MRS lipid signal to cervical cancer prognosis: a preliminary study
2022
Overview
Background
The aim of this study was to investigate the role of the lipid peak derived from
1
H magnetic resonance (MR) spectroscopy in assessing cervical cancer prognosis, particularly in assessing response to neoadjuvant chemotherapy (NACT) of locally advanced cervical cancer (LACC).
Methods
We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging sequences for pelvic assessment, the protocol included a single-voxel point-resolved spectroscopy (PRESS) sequence, with repetition time of 1,500 ms and echo times of 28 and 144 ms. Spectra were analysed using the LCModel fitting routine, thus extracting multiple metabolites, including lipids (Lip) and total choline (tCho). Patients with LACC were treated with NACT and reassessed by MRI at term. Based on tumour volume reduction, patients were classified as good responder (GR; tumour volume reduction > 50%) and poor responder or nonresponder (PR-or-NR; tumour volume reduction ≤ 50%).
Results
Of 17 patients, 11 were LACC. Of these 11, only 6 had both completed NACT and had good-quality
1
H-MR spectra; 3 GR and 3 PR-or-NR. A significant difference in lipid values was observed in the two groups of patients, particularly with higher Lip values and higher Lip/tCho ratio in PR-NR patients (
p
=0.040). A significant difference was also observed in choline distribution (tCho), with higher values in GR patients (
p
= 0.040).
Conclusions
Assessment of lipid peak at
1
H-MR spectroscopy could be an additional quantitative parameter in predicting the response to NACT in patients with LACC.
