Journal Article

Enhancement of mechanical properties of chitosan film by doping with sage extract-loaded niosomes

Mansouri, Sofiene, Elneklawi, Mona S, Abd-Elghany, Amr A, Ismail, Sameh H, Mohamad, Ebtesam A, El-Sakhawy, Mohamed A

2022

Overview

Chitosan films are increasingly being applied in the biomedical field owing to their biocompatibility, biodegradability, non-toxicity, mucoadhesive nature, hemostatic properties, antibacterial and biological activities. This study aimed to enhance the mechanical properties of chitosan films by doping niosomal sage nanoparticles (NS-SagNPs) at various concentrations (100–300 μ g). The NS-SagNPs were prepared by a thin-film hydration process with an average particle size of 21.5 nm. The doped chitosan films were fabricated through a simple casting method. FTIR and DSC measurements confirmed the successful incorporation of NS-SagNPs in the chitosan films. The mechanical properties of the doped films were improved and the most significant improvement was found in tensile strength and elasticity when the NS-SagNPs loading was increased to 300 μ g. Based on these results, chitosan films doped with NS-SagNPs have the advantageous feature of sage and show enhanced mechanical properties compared with pure chitosan, rendering them more suitable for biomedical applications.

• Publisher: IOP Publishing
• Subject: Biocompatibility / Biodegradability / Biological properties / Biomedical materials / Chitosan / Doped films / Doping / Mechanical properties / Nanoparticles / sage loaded niosomes / Tensile strength / Thin films / Toxicity