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Effect of two cleaning processes for bone allografts on gentamicin impregnation and in vitro antibiotic release
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Effect of two cleaning processes for bone allografts on gentamicin impregnation and in vitro antibiotic release
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Journal Article
Effect of two cleaning processes for bone allografts on gentamicin impregnation and in vitro antibiotic release
2013
Overview
Bone allografts are a useful and sometimes indispensable tool for the surgeon to repair bone defects. Microbial contamination is a major reason for discarding allografts from bone banks. To improve the number of safe allografts, we suggest chemical cleaning of the grafts followed by antibiotic impregnation. Comparison of two chemical cleaning processes for bone allografts aiming for antibiotic impregnation and consequently delivery rates in vitro. Bone chips of 5–10 mm were prepared from human femoral heads. Two cleaning methods (cleaning A and cleaning B) based on solutions containing hydrogen peroxide, paracetic acid, ethanol and biological detergent were carried out and compared. After the cleaning processes, the bone chips were impregnated with gentamicin.
Bacillus subtilis
bioassay was used to determine the gentamicin release after intervals of 1–7 days. Differences were compared with non-parametric Mann–Whitney
U
tests. The zones of inhibition obtained from the bone grafts cleaned with both cleaning processes were similar between the groups. The concentration of the released antibiotic was decreasing gradually over time, following a similar pattern for both groups. The cleaning procedure A as well as the cleaning procedure B for bone allografts allowed the impregnation with gentamicin powder in the same concentrations in both groups. The delivery of gentamicin was similar for both groups. Both cleaning procedures were easy to be carried out, making them suitable for routine use at the bone banks.
Publisher
Springer Netherlands,Springer Nature B.V
Subject
/ Anti-Bacterial Agents - administration & dosage
/ Anti-Bacterial Agents - metabolism
/ Anti-Bacterial Agents - pharmacology
/ Antibiotic Prophylaxis - methods
/ Bacillus subtilis - isolation & purification
/ Biomedical and Life Sciences
/ Bone Transplantation - methods
/ Bones
/ Gentamicins - administration & dosage
/ Humans
/ Hydrogen Peroxide - pharmacology
/ Powders
