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A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
by
Loebel, Antony
, Koblan, Kenneth S
, Hopkins, Seth C
, Cheng, Hailong
, Kent, Justine
, Krystal, John H
, Goldman, Robert
in
Acute Disease
/ Administration, Oral
/ Adult
/ Antipsychotic Agents - adverse effects
/ Antipsychotic Agents - therapeutic use
/ Antipsychotics
/ Clinical trials
/ Dopamine
/ Dopamine D2 receptors
/ Double-Blind Method
/ Drug Administration Schedule
/ Drug dosages
/ Extrapyramidal system
/ Female
/ Hemoglobin
/ Humans
/ Least-Squares Analysis
/ Lipids
/ Male
/ Mental disorders
/ Movement disorders
/ Neurons
/ Patients
/ Prolactin
/ Psychosis
/ Psychotropic drugs
/ Receptors, Dopamine D2
/ Receptors, G-Protein-Coupled - agonists
/ Schizophrenia
/ Schizophrenia - classification
/ Schizophrenia - drug therapy
/ Schizophrenic Psychology
/ Serotonin
/ Serotonin 5-HT1 Receptor Agonists - therapeutic use
/ Serotonin S1 receptors
/ Severity of Illness Index
/ Treatment Outcome
2020
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A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
by
Loebel, Antony
, Koblan, Kenneth S
, Hopkins, Seth C
, Cheng, Hailong
, Kent, Justine
, Krystal, John H
, Goldman, Robert
in
Acute Disease
/ Administration, Oral
/ Adult
/ Antipsychotic Agents - adverse effects
/ Antipsychotic Agents - therapeutic use
/ Antipsychotics
/ Clinical trials
/ Dopamine
/ Dopamine D2 receptors
/ Double-Blind Method
/ Drug Administration Schedule
/ Drug dosages
/ Extrapyramidal system
/ Female
/ Hemoglobin
/ Humans
/ Least-Squares Analysis
/ Lipids
/ Male
/ Mental disorders
/ Movement disorders
/ Neurons
/ Patients
/ Prolactin
/ Psychosis
/ Psychotropic drugs
/ Receptors, Dopamine D2
/ Receptors, G-Protein-Coupled - agonists
/ Schizophrenia
/ Schizophrenia - classification
/ Schizophrenia - drug therapy
/ Schizophrenic Psychology
/ Serotonin
/ Serotonin 5-HT1 Receptor Agonists - therapeutic use
/ Serotonin S1 receptors
/ Severity of Illness Index
/ Treatment Outcome
2020
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Do you wish to request the book?
A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
by
Loebel, Antony
, Koblan, Kenneth S
, Hopkins, Seth C
, Cheng, Hailong
, Kent, Justine
, Krystal, John H
, Goldman, Robert
in
Acute Disease
/ Administration, Oral
/ Adult
/ Antipsychotic Agents - adverse effects
/ Antipsychotic Agents - therapeutic use
/ Antipsychotics
/ Clinical trials
/ Dopamine
/ Dopamine D2 receptors
/ Double-Blind Method
/ Drug Administration Schedule
/ Drug dosages
/ Extrapyramidal system
/ Female
/ Hemoglobin
/ Humans
/ Least-Squares Analysis
/ Lipids
/ Male
/ Mental disorders
/ Movement disorders
/ Neurons
/ Patients
/ Prolactin
/ Psychosis
/ Psychotropic drugs
/ Receptors, Dopamine D2
/ Receptors, G-Protein-Coupled - agonists
/ Schizophrenia
/ Schizophrenia - classification
/ Schizophrenia - drug therapy
/ Schizophrenic Psychology
/ Serotonin
/ Serotonin 5-HT1 Receptor Agonists - therapeutic use
/ Serotonin S1 receptors
/ Severity of Illness Index
/ Treatment Outcome
2020
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A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
Journal Article
A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
2020
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Overview
In a randomized trial involving schizophrenic patients with acute psychosis, a new oral drug that does not have a dopamine D2-receptor–binding mechanism of action led to a greater reduction in the severity of overall symptoms than placebo over 4 weeks. The incidence of extrapyramidal symptoms was 3% with the new drug, a finding similar to that with placebo.
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Antipsychotic Agents - adverse effects
/ Antipsychotic Agents - therapeutic use
/ Dopamine
/ Drug Administration Schedule
/ Female
/ Humans
/ Lipids
/ Male
/ Neurons
/ Patients
/ Receptors, G-Protein-Coupled - agonists
/ Schizophrenia - classification
/ Schizophrenia - drug therapy
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