Journal Article

Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial

Tedesco, Antonio Claudio, Guimarães-Stabili, Morgana Rodrigues, Bellile, Emily, Retamal-Valdes, Belen, Rossa, Carlos, Pérez-Pacheco, Cindy Grace, Feres, Magda, Primo, Fernando Lucas, Fernandes, Natalie Ap. Rodrigues

2021

Overview

Objective Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy. Results PPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15. Conclusion We conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. Clinical relevance Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Chronic Periodontitis / Clinical trials / Curcumin / Dental Scaling / Dentistry / Double-blind studies / Follow-Up Studies / Gingival Crevicular Fluid / Gum disease / Humans / Hybridization / Interleukin 10 / Interleukin 6 / Medicine / Nanoparticles / Original Article / Periodontitis / Periodontitis - drug therapy / Placebos / Polylactide-co-glycolide / Root Planing / Tumor necrosis factor-α / Veillonella