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Severe polyserositis induced by the 13-valent pneumococcal conjugate vaccine: a case report
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Severe polyserositis induced by the 13-valent pneumococcal conjugate vaccine: a case report
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Journal Article
Severe polyserositis induced by the 13-valent pneumococcal conjugate vaccine: a case report
2017
Overview
Background
The United States Advisory Committee on Immunization Practices recommends administration of the 13-valent pneumococcal conjugate vaccine in series with the 23-valent pneumococcal polysaccharide vaccine for prevention of pneumonia in the elderly. Reports of autoimmune or auto-inflammatory diseases as a result of pneumococcal vaccination, especially pneumococcal conjugate vaccine, are extremely rare.
Case presentation
We present a case of severe serositis in a 75-year-old Caucasian woman complicated by pericardial and pleural effusions in the setting of recent 13-valent pneumococcal conjugate vaccine vaccination and no other obvious etiology. Our patient required steroid treatment, thoracentesis, chest tube, and pericardial window and subsequently recovered to her baseline.
Conclusions
To the best of our knowledge, no such reaction to the 13-valent pneumococcal conjugate vaccine has previously been documented. Although the benefits of vaccination outweigh the risks, knowledge of this potential side effect can help clinicians in diagnosis and treatment of similar patients.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Aluminum
/ Anti-Inflammatory Agents - therapeutic use
/ Biopsy
/ Blood
/ Disease
/ DNA
/ Drainage
/ Female
/ Funding
/ Humans
/ Medicine
/ Pericardial Effusion - chemically induced
/ Pericardial Effusion - immunology
/ Pericardial Effusion - therapy
/ Pleural Effusion - chemically induced
/ Pleural Effusion - immunology
/ Pneumococcal conjugate vaccine
/ Pneumococcal Vaccines - administration & dosage
/ Pneumococcal Vaccines - adverse effects
/ Prednisone - therapeutic use
/ Proteins
/ Serositis - chemically induced
/ Vaccination - adverse effects
/ Vaccines
