Journal Article

Hemorrhagic Shock and Massive Abdominal Wall Hematoma After Cesarean Section in a Patient with Peripartum Acquired Hemophilia A:A Case Report

Wu, Xiaohuan, Chen, Xiaojun, Xu, Shilian, Zheng, Xiaohang, Li, Xueyan, Zhang, Shuning, Fu, Shuai, Huang, Qiaoyao

2026

Overview

Acquired Hemophilia A (AHA), a rare bleeding disorder caused by autoimmune suppression of coagulation factor VIII(FVIII), has a low incidence in perinatal women but carries significant risks of severe hemorrhage. The lack of consensus guidelines and limited clinical data from developing countries underscore the importance of this case report. Consequently, this report informs clinical practice and expands the evidence base for the treatment of AHA. This case describes an extensive abdominal wall hematoma and hemorrhagic shock following a cesarean section in a patient. The condition was successfully managed through comprehensive interventions, including shock resuscitation, endovascular embolization, pharmacological hemostatic therapy, removal of circulating immune complexes, and immunosuppressive therapy. AHA usually causes acute bleeding, and early identification and removal of acquired inhibitors are the main treatment methods. In such cases, endovascular embolization is an effective procedure to control bleeding.

• Publisher: Dove Press,Dove Medical Press
• Subject: Acquired hemophilia A / activated partial thromboplastin time / Case Report / endovascular embolization / factor VIII inhibitors / factor VIII inhibitors;endovascular embolization / perinatal