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Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Acinetobacter baumannii Endemic in New York City
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Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Acinetobacter baumannii Endemic in New York City
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Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Acinetobacter baumannii Endemic in New York City
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Journal Article
Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Acinetobacter baumannii Endemic in New York City
2003
Overview
Multidrug-resistant Acinetobacter baumannii has emerged as a serious nosocomial pathogen in certain areas. In Brooklyn, New York, citywide surveillance revealed that ∼2 of every 3 isolates were resistant to carbapenem antibiotics. Genetic fingerprinting revealed that 2 strains accounted for 82% of these resistant isolates. Compared with carbapenem-susceptible isolates, carbapenem-resistant isolates had reduced expression of 47-, 44-, and 37-kDa outer-membrane proteins. No specific carbapenemase was found; however, carbapenem-resistant isolates expressed greater levels of a class C cephalosporinase. Although expression of penicillin-binding proteins varied among strains, no consistent pattern appeared to account for carbapenem resistance. An efflux pump, present in several strains, did not appear to contribute to carbapenem resistance. Clonal spread of carbapenem-resistant A. baumannii has occurred in hospitals in Brooklyn. The preliminary findings for a small number of strains suggest that diminished production of outer-membrane porins, together with increased expression of a class C cephalosporinase, appear to be important factors leading to carbapenem resistance in this region.
Publisher
The University of Chicago Press,University of Chicago Press
Subject
/ Acinetobacter baumannii - chemistry
/ Acinetobacter baumannii - drug effects
/ Acinetobacter Infections - epidemiology
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Bacterial Outer Membrane Proteins - analysis
/ Biological and medical sciences
/ Enzymes
/ Gels
/ Humans
/ Muramoylpentapeptide Carboxypeptidase - analysis
/ New York City - epidemiology
/ Pharmacology. Drug treatments
/ Pumps
/ Qualia
