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Reintroduction of Clozapine following Neuroleptic Malignant Syndrome in a Young Patient with Resistant Schizophrenia
by
Kodad, Safae
, Chlihfane, Rajae
, Chandad, Miriam
, Oneib, Bouchra
, Elghazouani, Fatima
in
Antipsychotics
/ Care and treatment
/ Case Report
/ Case reports
/ Clozapine
/ Consent
/ Dehydrogenases
/ Development and progression
/ Drug dosages
/ Dyskinesia
/ Electroconvulsive therapy
/ Emergency medical care
/ Health aspects
/ Neuroleptic malignant syndrome
/ Patients
/ Psychosis
/ Psychotropic drugs
/ Schizophrenia
2024
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Reintroduction of Clozapine following Neuroleptic Malignant Syndrome in a Young Patient with Resistant Schizophrenia
by
Kodad, Safae
, Chlihfane, Rajae
, Chandad, Miriam
, Oneib, Bouchra
, Elghazouani, Fatima
in
Antipsychotics
/ Care and treatment
/ Case Report
/ Case reports
/ Clozapine
/ Consent
/ Dehydrogenases
/ Development and progression
/ Drug dosages
/ Dyskinesia
/ Electroconvulsive therapy
/ Emergency medical care
/ Health aspects
/ Neuroleptic malignant syndrome
/ Patients
/ Psychosis
/ Psychotropic drugs
/ Schizophrenia
2024
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Reintroduction of Clozapine following Neuroleptic Malignant Syndrome in a Young Patient with Resistant Schizophrenia
by
Kodad, Safae
, Chlihfane, Rajae
, Chandad, Miriam
, Oneib, Bouchra
, Elghazouani, Fatima
in
Antipsychotics
/ Care and treatment
/ Case Report
/ Case reports
/ Clozapine
/ Consent
/ Dehydrogenases
/ Development and progression
/ Drug dosages
/ Dyskinesia
/ Electroconvulsive therapy
/ Emergency medical care
/ Health aspects
/ Neuroleptic malignant syndrome
/ Patients
/ Psychosis
/ Psychotropic drugs
/ Schizophrenia
2024
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Reintroduction of Clozapine following Neuroleptic Malignant Syndrome in a Young Patient with Resistant Schizophrenia
Journal Article
Reintroduction of Clozapine following Neuroleptic Malignant Syndrome in a Young Patient with Resistant Schizophrenia
2024
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Overview
The incidence of neuroleptic malignant syndrome justifies the immediate discontinuation of the drug in question and the reinstitution of therapy with another drug. In the case of resistant schizophrenia treated with clozapine, there are insufficient therapeutic options. We report the case of a young patient followed up for resistant schizophrenia who developed neuroleptic malignant syndrome after 5 years of therapy with clozapine. Clozapine therapy was successfully reinitiated, and the dosage was increased to 300 mg/day over 62 days. In light of this clinical case and a review of the literature, we report the possibility of reintroducing clozapine following an incidence of malignant syndrome in patients with resistant schizophrenia with respect to certain rules; in particular, a slow increase in dose after a reasonable period of time and close monitoring.
Publisher
Hindawi,John Wiley & Sons, Inc,Wiley
Subject
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