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Bacterial DNA repair: recent insights into the mechanism of RecBCD, AddAB and AdnAB
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Bacterial DNA repair: recent insights into the mechanism of RecBCD, AddAB and AdnAB
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Journal Article
Bacterial DNA repair: recent insights into the mechanism of RecBCD, AddAB and AdnAB
2013
Overview
Repair of double-strand DNA breaks by homologous recombination can be carried out in bacteria by RecBCD, AddAB and AdnAB. Here, Dale Wigley discusses recent insights into how these complexes mediate repair, as well as their evolution.
In bacteria, the processing of double-strand DNA breaks is mediated by the RecBCD, AddAB and AdnAB complexes. These multisubunit helicase–nuclease machines resect the DNA ends and load RecA protein to initiate homologous recombination. Recent studies have revealed fascinating insights into the molecular mechanisms of this process and the evolution of these machines.
Publisher
Nature Publishing Group UK,Nature Publishing Group
