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Randomized Trial of Vaccines for Zaire Ebola Virus Disease

by Samai, Mohamed , Dighero-Kemp, Bonnie , Wiedemann, Aurélie , Watson-Jones, Deborah , Chêne, Geneviève , Yazdanpanah, Yazdan , Millimouno, Niouma P , Diallo, Alpha , Lees, Shelley , Levy, Yves , Richert, Laura , Doumbia, Seydou , Greenwood, Brian , Faye, Sylvain , Beavogui, Abdoul H , Grund, Birgit , Vatrinet, Renaud , Espérou, Hélène , D'Ortenzio, Eric , Leigh, Bailah , Pierson, Jerome , Camara, Alseny M , McLean, Chelsea , Hensley, Lisa , Neaton, James , Roy, Céline , Wentworth, Deborah , Lhomme, Edouard , Simon, Jakub , Kieh, Mark , Lane, H Clifford , Piot, Peter , Deen, Gibrilla F , Sow, Samba , Kennedy, Stephen B , Doumbia, Moussa

in Adult / Age groups / Antibodies / Antibodies, Viral / Antibody response / Biomedical research / Child / Children / Clinical trials / Confidence intervals / Democratic Republic of the Congo / Ebola Vaccines - therapeutic use / Ebola virus / Ebolavirus / Enzyme-linked immunosorbent assay / Global Health / Glycoproteins / Hemorrhagic Fever, Ebola - prevention & control / Humans / Immune response / Immunization / Infectious Disease / Infectious Disease General / Laboratories / Life Sciences / Placebos / Safety / Statistical analysis / Vaccines / Viral Infections / Viruses

2022

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2022

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2022

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Journal Article

Randomized Trial of Vaccines for Zaire Ebola Virus Disease

Samai, Mohamed,

Dighero-Kemp, Bonnie,

Wiedemann, Aurélie,

Watson-Jones, Deborah,

Chêne, Geneviève,

Yazdanpanah, Yazdan,

Millimouno, Niouma P,

Diallo, Alpha,

Lees, Shelley,

Levy, Yves,

Richert, Laura,

Doumbia, Seydou,

Greenwood, Brian,

Faye, Sylvain,

Beavogui, Abdoul H,

Grund, Birgit,

Vatrinet, Renaud,

Espérou, Hélène,

D'Ortenzio, Eric,

Leigh, Bailah,

Pierson, Jerome,

Camara, Alseny M,

McLean, Chelsea,

Hensley, Lisa,

Neaton, James,

Roy, Céline,

Wentworth, Deborah,

Lhomme, Edouard,

Simon, Jakub,

Kieh, Mark,

Lane, H Clifford,

Piot, Peter,

Deen, Gibrilla F,

Sow, Samba,

Kennedy, Stephen B,

Doumbia, Moussa

2022

Overview

In two randomized trials of Zaire Ebola vaccines, safety and immune responses in adults and children were assessed for three regimens with two different vaccines. All three induced immune responses lasting at least 1 year.

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Publisher

Massachusetts Medical Society

Subject

/ Biomedical research

/ Child