Journal Article

Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents

Burger, David M., Alffenaar, Jan-Willem C., Verweij, Paul E., Kosterink, Jos G. W., Saravolatz, Louis D., Brüggemann, Roger J. M., Blijlevens, Nicole M. A., Billaud, Eliane M.

2009

Overview

There are currently a number of licensed azole antifungal drugs; however; only 4 (namely, fluconazole, itraconazole, posaconazole, and voriconazole) are used frequently in a clinical setting for prophylaxis or treatment of systemic fungal infections. In this article, we review the pharmacokinetic interactions of these azole antifungal drugs with other coadministered agents. We describe these (2-way) interactions and the extent to which metabolic pathways and/or other supposed mechanisms are involved in these interactions. This article provides an overview of all published drug-drug interactions in humans (either healthy volunteers or patients), and on the basis of these findings, we have developed recommendations for managing the specific interactions.

• Publisher: The University of Chicago Press,University of Chicago Press,Oxford University Press
• Subject: Antibiotics. Antiinfectious agents. Antiparasitic agents / Antifungal agents / Antifungal Agents - pharmacokinetics / Antifungal Agents - pharmacology / Antifungals / Azoles / Azoles - pharmacokinetics / Azoles - pharmacology / Bioavailability / Biological and medical sciences / Cytochromes / Dosage / Drug Interactions / Enzymes / Fungal infections / Humans / Infectious diseases / Medical sciences / Medical treatment / Metabolism / Pharmacokinetics / Pharmacology / Pharmacology. Drug treatments / Prescription drugs / Prophylaxis / Reviews of Anti-Infective Agents / Volunteerism