Asset Details
Do you wish to reserve the book?
Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells
Do you wish to request the book?
Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells
2011
Overview
The generation of CD8
+
T cell memory requires both CD4
+
T cells and dendritic cells. Schoenberger
et al
. show that autocrine production of interleukin 2 by licensed CD8
+
T cells is also crucial.
Two competing theories have been put forward to explain the role of CD4
+
T cells in priming CD8
+
memory T cells: one proposes paracrine secretion of interleukin 2 (IL-2); the other proposes the activation of antigen-presenting cells (APCs) via the costimulatory molecule CD40 and its ligand CD40L. We investigated the requirement for IL-2 by the relevant three cell types
in vivo
and found that CD8
+
T cells, rather than CD4
+
T cells or dendritic cells (DCs), produced the IL-2 necessary for CD8
+
T cell memory.
Il2
−/−
CD4
+
T cells were able to provide help only if their ability to transmit signals via CD40L was intact. Our findings reconcile contradictory elements implicit in each model noted above by showing that CD4
+
T cells activate APCs through a CD40L-dependent mechanism to enable autocrine production of IL-2 in CD8
+
memory T cells.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ CD4-Positive T-Lymphocytes - cytology
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ CD8-Positive T-Lymphocytes - cytology
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - metabolism
/ Dendritic Cells - immunology
/ Dendritic Cells - metabolism
/ Listeria monocytogenes - growth & development
/ Mice
We currently cannot retrieve any items related to this title. Kindly check back at a later time.