Asset Details
Do you wish to reserve the book?
Intestinal Permeability in the Assessment of Intestinal Toxicity of Cytotoxic Agents
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Intestinal Permeability in the Assessment of Intestinal Toxicity of Cytotoxic Agents
Do you wish to request the book?
Intestinal Permeability in the Assessment of Intestinal Toxicity of Cytotoxic Agents
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Intestinal Permeability in the Assessment of Intestinal Toxicity of Cytotoxic Agents
2005
Overview
The diagnosis and assessment of the severity of intestinal mucosal damage in cancer patients treated with cytotoxic drugs still rely on anamnestic data. There is cumulative evidence that measurement of intestinal permeability may represent a sensitive indicator of intestinal damage by cytotoxic agents. The intestinal permeability testing is based on differential permeability of tight junctions along the crypt-villus axis to nonmetabolized sugars. Cytotoxic drugs induce flattening of villi, leading to increased exposure of luminal contents to crypts and increased disaccharide absorption. An increased disaccharide/monosaccharide ratio and decreased xylose absorption have been described in patients treated with different cytotoxic drugs across a spectrum of malignant tumors that correlated with clinical manifestations, and were used to monitor the effect of therapeutic interventions.
Publisher
Karger,S. Karger AG
Subject
/ Antineoplastic Agents - adverse effects
/ Biological and medical sciences
/ Cancer
/ Drug toxicity and drugs side effects treatment
/ Humans
/ Intestinal Diseases - chemically induced
/ Intestinal Diseases - diagnosis
/ Intestinal Mucosa - drug effects
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - metabolism
/ Miscellaneous (drug allergy, mutagens, teratogens...)
/ Mucositis - chemically induced
/ Pharmacology. Drug treatments
/ Toxicity
