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Virulence potential for extraintestinal infections among commensal Escherichia coli isolated from healthy humans—the Trojan horse within our gut
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Virulence potential for extraintestinal infections among commensal Escherichia coli isolated from healthy humans—the Trojan horse within our gut
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Journal Article
Virulence potential for extraintestinal infections among commensal Escherichia coli isolated from healthy humans—the Trojan horse within our gut
2015
Overview
Previous investigations have indicated that the reservoir of extraintestinal pathogenic Escherichia coli (ExPEC) strains is the intestinal microbiota. Nevertheless, studies focused on the prevalence of potential ExPEC strains among the bowel microbiota in healthy human individuals practically do not exist and a strong bias towards pathogenic strains among the E. coli data set is obvious. To assess the prevalence of potential ExPEC strains among E. coli from the intestinal microbiota of healthy humans, we performed a search for data on the prevalence of virulence-associated genes and pathogenicity islands among fecal E. coli found in published studies, including studies comparing isolates from patients suffering from extraintestinal E. coli infections with E. coli from feces of healthy humans. An extensive literature search, including more than 500 published papers, revealed 24 papers with data on prevalences of ≥5 virulence-associated genes among 21 E. coli collections including ≥20 fecal/rectal strains obtained from healthy individuals and 4 papers with prevalences of pathogenicity islands among E. coli collections from healthy humans. The gathered data are presented in this minireview and clearly show that potential ExPEC strains are present among fecal isolates with a prevalence of around ≥10%.
The commensal E. coli within us may act as a Trojan horse that can instigate a pathogenic process and damage their host.
Publisher
Oxford University Press
Subject
