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Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
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Journal Article
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
2024
Overview
Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus. In recent years, basic and clinical studies have shown that GLP-1 is closely related to lipid metabolism, and it can participate in lipid metabolism by inhibiting fat synthesis, promoting fat differentiation, enhancing cholesterol metabolism, and promoting adipose browning. GLP-1 plays a key role in the occurrence and development of metabolic diseases such as obesity, nonalcoholic fatty liver disease, and atherosclerosis by regulating lipid metabolism. It is expected to become a new target for the treatment of metabolic disorders. The effects of GLP-1 and dual agonists on lipid metabolism also provide a more complete treatment plan for metabolic diseases. This article reviews the recent research progress of GLP-1 in lipid metabolism.
Publisher
Korean Diabetes Association / Daehan Dangnyobyeong Hakoe,Korean Diabetes Association,대한당뇨병학회
Subject
/ Agonists
/ Animals
/ Atherosclerosis - drug therapy
/ Atherosclerosis - metabolism
/ Body fat
/ Genes
/ Glucagon
/ Glucagon-Like Peptide 1 - metabolism
/ Glucose
/ Humans
/ Kinases
/ Lipid Metabolism - drug effects
/ Lipids
/ non-alcoholic fatty liver disease
/ Non-alcoholic Fatty Liver Disease - drug therapy
/ Non-alcoholic Fatty Liver Disease - metabolism
/ obesity
/ Peptides
/ Proteins
/ 내과학
