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One‐Step Method for Instant Generation of Advanced Allogeneic NK Cells
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One‐Step Method for Instant Generation of Advanced Allogeneic NK Cells
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Journal Article
One‐Step Method for Instant Generation of Advanced Allogeneic NK Cells
2018
Overview
Conventional combinatorial anticancer therapy has shown promising outcomes; still, a significant interest in developing new methods to reinforce and possibly merge chemotherapy and immunotherapy persists. Here, a new one‐step method that immediately modifies immune cells into a targeted form of chemoimmunotherapy through spontaneous and rapid incorporation of hydrophobized antibody–drug conjugates (ADCs) on the surface of immune cells is presented. Therapeutic objectives of this approach include targeted delivery of a potent chemotherapeutic agent to avoid adverse effects, enhancing the mobilization of infused immune cells toward tumor sites, and preserving the intense cytotoxic activities of immune cells against tumor cells. The embedding of hydrophobized ADCs on the immune cell membrane using the strategy in this study provides noninvasive, nontoxic, and homogenous modifications that transiently arm immune cells with highly potent cytotoxic drugs targeted toward cancer cells. The resulting surface‐engineered immune cells with ADCs significantly suppress the tumor growth and drive the eradication of target cancer cells through combinatorial anticancer effects. This novel strategy allows convenient and timely preparation of advanced chemoimmunotherapy on a single immune cell to treat various types of cancer. Advanced natural killer (NK) cells, instantaneously prepared using a one‐step method, are surface‐engineered with antibody–drug conjugates (ADCs). Combining chemotherapy and immunotherapy in a single cell, these specialized NK cells can target specific tumor cells through antigen recognition, deliver potent chemotherapeutic agents, and destroy tumor cells. Surface engineering of NK cells with ADCs may become an “off‐the‐shelf” reagent for various types of cancer.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
