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Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis
Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis
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Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis
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Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis
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Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis
Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis
Journal Article

Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis

2022
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Overview
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that predominantly affects the axial skeleton, although it can affect peripheral joints, and extra-musculoskeletal manifestations also occur. Historically, axSpA was thought to be a disease predominantly seen in men, although with the advent of magnetic resonance imaging techniques and advances in research, this dogma has been challenged and refuted. Sex and gender are different concepts, and both can have a role in disease. In axSpA, consideration of the influence of sex and gender on the disease phenotype is necessary to predict outcomes and to enable the development of therapeutic approaches that are best suited to individual patients.In this Review, the authors discuss the roles of sex and gender in relation to axial spondyloarthritis. Although evidence now suggests that the disease has equal prevalence in men and women, important differences occur in phenotypes, response to therapy and outcomes.